Current chemical manufacturing processes are not sustainable. Most chemicals are derived from petroleum-based resources and synthesized using chemical routes that pollute the environment and endanger human health.
Traditional chemical companies have been slow in adopting bio-based processes. One major impediment is that petroleum-based chemicals are far cheaper to produce and the chemical synthesis routes are well-established, making it challenging and highly risky for companies to switch to biosynthetic routes. These issues are particularly pertinent to the chemical sector in Hong Kong that comprises mostly of small and medium enterprises (SMEs) which have limited financial means, technology and talents to invest in green manufacturing.

We have developed a robust, customizable and cost-effective platform for the production of immobilized enzyme catalysts for the biosynthesis of commodity and specialty chemicals. Distinct from most existing approaches that encompass multiple processes from expression, purification to chemical conjugation, our technology simplifies all these steps into a simple procedure that utilizes bacteria as the workhorse to directly produce the desired biocatalysts. These enzyme-based biocatalysts are highly specific allowing for better control over the desired reaction, leading to product consistency and high product purity. The chemicals produced can be used directly in subsequent synthetic reactions without further purification. These advantages significantly reduce the production cost of bio-based chemicals, enabling them to become more cost competitive with their petroleum-based counterparts. Notably, we have already demonstrated the production of putrescine and cadaverine from our catalysts and their use to produce bio-nylon.

Our project will enhance industries awareness  that sustainable production of chemicals is economically feasible, and help advance the adoption of green routes for other chemicals production, and ultimately the transition toward more socially and environmentally responsible chemical industries.

Primary Beneficiary:

• Chemical companies [15-30]

Secondary Beneficiary:

• Textile and fibre manufacturers [>100]


• Automotive and electronic component manufacturers [>10000]


• Consumers

2025

Sustainability